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aged garlic and Gum disease

Formulation and evaluation of aged garlic in situ gel as a potential local drug delivery agent compared to chlorhexidine gluconate for the management of chronic periodontitis

Status
Recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045956
Enrollment
45
Registered
2022-09-27
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: A488- Other specified bacterial diseases

Interventions

Intervention1: aged garlic gel: aged garlic gel to be placed once in periodontal pocket of patients with chronic periodontitis 15 days after 15 days Control Intervention1: 1.5% chlorhexidine gel: 1.5%

Sponsors

Dr Meghana Sunil
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Participants without any ongoing systemic disease/medical condition 2. Participants with less than 10 sites with residual periodontal pockets both right and left side of the 3. maxillary premolar and molar with pocket depth >= 5 mm 4. Presence of a minimum of 20 natural teeth.

Exclusion criteria

Exclusion criteria: 1. Participants with a history of any systemic disease/conditions such as diabetes, hypertension, hyperlipidemia etc. 2. Participants with any history of any drug intake/medication for systemic disease 3. Participants reporting any allergy to chlorhexidine. 4. Current and former smokers 5. Participants with any form of oral abusive habit such as ghutka, pan, supari, arecanut,etc 6. Those undergoing any radiation or chemotherapy 7. Pregnant and lactating women. 8. Participants who have undergone any periodontal therapy in the previous six months. 9. Participants who are under any antibiotics in previous three months

Design outcomes

Primary

MeasureTime frame
pocket depth and clinical attachment lossTimepoint: baseline, 15 days (gel placement), 15 days after gel placement, 45 days

Secondary

MeasureTime frame
gingival index, plaque index, bleeding on probing, , total antioxidant capacity of GCF, microbial profile Timepoint: baseline, 15 days (gel placement), 15 days after gel placement, 45 days

Countries

India

Contacts

Public ContactMeghana Sunil

Manipal College of Dental Sciences, Manipal

aditi.chopra@manipal.edu9739863908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026