Health Condition 1: C00-D49- Neoplasms
Conditions
Interventions
None listed
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1] Advanced Cancer patients. 2] Patient should be on best supportive care only. 3] Newly referred or on follow up in department of Palliative Medicine. 4] Patient should be newly started on any strong opioids. 5] Patient started on antiemetic as prophylaxis or treatment for OINV. 6] Age above 18 years and willing to participate. 7] Patient must have a caregiver > 18 years of age 8] Able to communicate and understand English/Hindi/Marathi. 9] Able to give written informed consent for questionnaire administration
Exclusion criteria
Exclusion criteria: 1. Patients on pre-existing psychotropic medications like haloperidol or olanzapine, which are used as anti-emetics. 2. Patients on already on antiemetics. 3. Patients with unstable medical condition requiring any emergency treatment. 4. Patients should not have cognitive impairment preventing patients from comprehending questionnaire. 5. Patients with refractory nausea vomiting (not controlled with three different antiemetics). 6. Patients if they had other known acute reasons for nausea and/or emesis, e.g.: a. were undergoing chemotherapy treatment period; b. were undergoing radiotherapy to the skull or abdomen during the study treatment period; c. were undergoing surgical procedures or non-invasive procedures under general anaesthesia 7. Patients in end of life and actively dying.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total number of episodes of vomiting at 72hrs from starting of strong opioids, as reported by patient.Timepoint: 72 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1] Difference in nausea from starting of strong opioids till 72 hrs, as assessed by ESAS-R scoring Timepoint: 72 hours;2] Difference in NOSE score from start of strong opioids till 72 hrs.Timepoint: 72 hours;3] Difference in nausea from starting of strong opioids till 7 days, as assessed by ESAS-R scoringTimepoint: Day 7;4] Difference in NOSE score from start of strong opioids till 7 days.Timepoint: Day 7;5] Total number of PRN doses of antiemetics taken till 72hrs from start of strong opioids as reported by patient.Timepoint: 72 hours;6] Total number of PRN doses of antiemetics taken till day 7 from start of strong opioids as reported by patient. Timepoint: Day 7;7] Total number of doses of antiemetics taken prophylactic regular doses plus PRN till day 7 of start of strong opioids as reported by patient.Timepoint: Day 7;8] Total number of patients in whom antiemetics were changed/ combinations are required from day 0 to day 7.Timepoint: Day 0 to day 7 | — |
Countries
India
Contacts
Public ContactDr Dhanashri Kudal
Tata Memorial Hospital
Outcome results
None listed