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A study to compare the effects of two types of ventilatory methods on brain blood flow, oxygenation in brain and the change in pressure inside the skull.

Effect of intraoperative lung protective ventilation on cerebral hemodynamics (cerebral blood flow assessment using transcranial doppler, cerebral oxygenation by NIRS and ICP measurement using subdural catheter) in neurosurgical patients: a prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/09/045844
Enrollment
34
Registered
2022-09-26
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system

Interventions

None listed

Sponsors

SCTIMST
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Consenting adult patients undergoing craniotomy in supine position or anterior spinal surgery at Sree Chitra Tirunal Institute for Medical Sciences and Technology 2.Age 18-60 yrs. 3. ASA (American Society of Anaesthesiologists) class 1 and 2 4. GCS 15 prior to the surgery

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Craniotomies other than supine position 3. Spine surgeries in prone position 4. Recent respiratory infection 5. Patients with chronic lung disease or pulmonary infections 1 month before surgery 6. Acute respiratory failure (pneumonia, acute lung injury, ARDS) 7. Emergency surgery 8. Patients with clinical signs (head ache, vomiting, confusion, papilledema, pupillary asymmetry) or radiological signs (midline shift > 1cm, presence of hydrocephalus) of raised intracranial pressure preoperatively. 9. Long standing uncontrolled diabetes mellitus, systemic hypertension, cardiovascular disease, COPD 10. Patients with previous history of stroke, transient ischemic attacks 11. Obesity 12. ASA class 3,4,5 patients 13. Patients with subarachnoid haemorrhage, vasospasm 14. Pregnant and lactating mothers 15. Any abnormality in baseline NIRS and TCD values

Design outcomes

Primary

MeasureTime frame
: comparison of cerebral oxygenation (NIRS), cerebral blood flow and intracranial pressure during conventional tidal volume ventilation and lung protective type of mechanical ventilation in patients undergoing neurosurgical procedures.Timepoint: 2 time points: conventional ventilation and lung protective ventilation—

Secondary

MeasureTime frame
: comparison of changes in systemic hemodynamics and dynamic ventilatory parameters during normal tidal volume and lung protective ventilation and its effect on cerebral hemodynamics in patients undergoing neurosurgical procedures.Timepoint: 2 time points: conventional ventilation and lung protective ventilation—

Countries

India

Contacts

Public ContactDr S Manikandan

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

kanmanis@sctimst.ac.in9446334711

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026