Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: Dexmedetomidine 0.5 mcg/kg/h will be administered as continuous infusion after anesthetic induction till end of surgery.
Control Intervention1: Fentanyl: Fentanyl will
Sponsors
Sriganesh Kamath
Eligibility
Inclusion criteria
Inclusion criteria: All consecutive consenting adult patients undergoing elective craniotomies for supratentorial brain tumors with Glasgow Coma Scale score of 15 will be included in this trial.
Exclusion criteria
Exclusion criteria: We will exclude patients from this trial if they do not consent or if they have a current or past history of ischemic heart disease, cardiac failure (New York Heart Association grade >= 3), heart block or arrhythmia, untreated hypertension and diabetes mellitus, emergency surgery, pre-existing pain and receiving regular long-term drugs to manage pain, history of vomiting, previous cranial surgery, allergy to study drugs and opioid dependence as per the Diagnostic and Statistical Manual of mental disorders IV criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Rescue fentanyl consumption during surgery 2.Postoperative pain using Numerical Rating Scale score Timepoint: 1.During surgery 2.After surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse eventsTimepoint: During and upto 60 minutes after surgery;Patient satisfactionTimepoint: 24 hours after surgery;Persistent pain and quality of lifeTimepoint: At 3 and 6 months after surgery;Quality of recovery from anesthesia and emergence deliriumTimepoint: End of anesthesia till 60 minutes after surgery;Quality of sleepTimepoint: 1st postoperative day | — |
Countries
India
Contacts
Public ContactSriganesh Kamath
National Institute of Mental Health and Neurosciences, Bengaluru
Outcome results
None listed