Health Condition 1: N040- Nephrotic syndrome with minor glomerular abnormality
Conditions
Interventions
Intervention1: Intravenous furosemide infusion alone: Intravenous furosemide bolus 2 mg/kg to achieve a steady state serum concentration, followed by IV furosemide infusion @ 0.5 mg/kg/hr for 12 hours
Sponsors
Chacha Nehru Bal Chikitsalaya
Eligibility
Inclusion criteria
Inclusion criteria: Children, between 1-12 years of age, with nephrotic syndrome and refractory edema ( <1% weight loss per day for 5 consecutive days or <5% cumulative weight loss by 5th day of hospitalization after receiving maximum oral dose of furosemide, hydrochlorothiazide or metolazone and IV furosemide bolus in sequence) will be enrolled for the study
Exclusion criteria
Exclusion criteria: 1.Known secondary causes of nephrotic syndrome or with features of glomerulonephritis; like gross hematuria, hypertension, oliguria and deranged kidney function. 2.Children with acute diarrhoea 3.Clinical features of hypovolemia 4.With AKI stage II or III according to KDIGO definition and classification criteria for AKI 5.Children with severe systemic infections; like pneumonia, peritonitis, cellulitis or sepsis 6.Children with respiratory distress
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the mean difference in percentage weight loss at 24 hours in children with nephrotic syndrome and refractory edema receiving furosemide infusion in comparison to those receiving albumin-furosemide combinationTimepoint: 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Mean difference in percentage weight loss between two groups. Timepoint: at 48 and 72 hours of therapy | — |
Countries
India
Contacts
Public ContactNaman Kumar
Chacha Nehru Bal Chikitsalaya, Delhi
Outcome results
None listed