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The comparison of effectiveness of two drugs given via injection in the lower back for pain management in patients undergoing laparoscopic uterine removal surgery.

Analgesic Efficacy of intrathecal dexmeditomedine versus intrathecal morphine as adjuvants to bupivacaine in Patients Undergoing Total Laparoscopic Hysterectomy: A randomized parallel-group double-blind non-inferiority trial

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045697
Enrollment
96
Registered
2022-09-20
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group ITD: These patients receive sub arachnoid block with 5mg bupivacaine and 5mcg of dexmeditomedine as adjuvant at L3-L4 interspace, using proper aseptic precautions before induction

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 or ASA 2 patients undergoing elective total laparoscopic hysterectomy

Exclusion criteria

Exclusion criteria: � Patient refusal to participate. � Known hypersensitivity to local anaesthetic and opioids. � Patient having an infection at the site of intervention. � Patient having spinal deformities and previous history of spine surgery. � Patients on anticoagulation therapy. � Patients with untreated psychiatric illness that would interfere with pain perception and assessment � Patients with history of drug or alcohol abuse � Patients with BMI > 30kg/m2 � Patients with symptomatic cardiac and or respiratory disease. � Regular use of opioids � History of shoulder trauma or surgery

Design outcomes

Primary

MeasureTime frame
cumulative fentanyl consumption Timepoint: 24hours

Secondary

MeasureTime frame
� Duration of analgesia(time for the first analgesia injection in postoperative period). � 11-point NRS scores at rest and at movement in postoperative period at the time interval of 2 hours, 4 hours, 6 hours,12 hours and 24 hours. � Adverse events in 24 hours � Patient satisfaction score. Timepoint: 24 hours

Countries

India

Contacts

Public ContactDr Christopher Dass

All India Institute of Medical Science

christopherdass25@gmail.com9560177416

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026