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To study the impact of individualised ventilation in patients under general anaesthesia as compared to those receiving conventional ventilation.

Effect of recruitment maneuver and optimum PEEP on Optic nerve sheath diameter, oxygenation, ventilation, and inflammatory response in major abdominal surgeries- a randomized, pilot study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045638
Enrollment
60
Registered
2022-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C15-C26- Malignant neoplasms of digestive organs

Interventions

Intervention1: Type of Ventilation: Patient undergoing major abdominal surgery under general anaesthesia will receive mechanical ventilation with periodic recruitment manoeuvre and optimum PEEP Contro

Sponsors

All India Institute of Medical Sciences Rishikesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: - ASA physical status i-iii - BMI - Candidates posted for abdominal surgeries and surgical duration expected to exceed beyond 2 hours

Exclusion criteria

Exclusion criteria: - Mechanical ventilation of > 1 hour within the last 2 weeks before surgery - Body mass index � 35 kg/m2 - Acute respiratory failure (pneumonia, acute lung injury or acute respiratory distress syndrome) - Laparoscopic surgery - Sepsis or septic shock - Progressive neuromuscular illness - Intra-thoracic surgery - Pregnancy - Orbital tumors - Optic neuritis - Glaucoma - Refusal to participate

Design outcomes

Primary

MeasureTime frame
Optic Nerve Sheath Diameter in patients of both groupsTimepoint: Baseline, 1 hour and 2 hours from induction of anaesthesia—

Secondary

MeasureTime frame
Neutrophil:Lymphocyte RatioTimepoint: Pre-operatively and 24 hours post-operatively;PaO2, P:F, Driving Pressure, ComplioanceTimepoint: Baseline, 1 hour and 2 hours from induction of anaesthesia—

Countries

India

Contacts

Public ContactDr Praveen Talawar

All India Institute of Medical Sciences, Rishikesh

praveenrt64@gmail.com9654162941

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026