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A randomised control study to know the efficacy of oral medications like melatonin, pregabalin and clonidine in controlling the blood pressure and heart rate during laryngoscopy and intubation in patients undergoing laparoscopic cholecystectomy.

A STUDY ON EFFICACY OF ORAL MELATONIN, PREGABALIN AND CLONIDINE IN ATTENUATING HEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA, A RANDOMISED CONTROL TRIAL.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045635
Enrollment
105
Registered
2022-09-19
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: Melatonin , pregabalin and clonidine : Group 1 will receive 6mg melatonin Group 2 will receive 150mg pregabalin Group 3 will receive 200mcg clonidine Drugs will be given orally 2 ho

Sponsors

Adyasha Singh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II patients posted for laparoscopic cholecystectomy.

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. History of allergy to the drugs used in the study. 3. Patients with psychiatric disorders. 4. Patients on anti-hypertensive medications 5. Pregnancy 6. Renal/hepatic disease, morbid obesity. 7. Patient receiving treatment with any of the study drug. 8. Anticipated difficult airway

Design outcomes

Primary

MeasureTime frame
Attenuation in hemodynamic response (MAP)Timepoint: MAP recorded at baseline, before induction, at intubation and at 1,3,5,10,15th min—

Secondary

MeasureTime frame
sedation score anxiety score postoperative analgesia requirementTimepoint: till 12hours of postoperative period—

Countries

India

Contacts

Public ContactAdyasha Singh

Kalinga Institute of Medical Sciences

mousumi.das1503@gmail.com9937928790

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026