Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Sponsors
IGBI
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients of Indian origin/ethnicity 2.Patients with histopathological proven invasive breast cancer of any pathological subtype. 3.Female patients who are older than 18 years of age. 4.Patients who are willing to provide written informed consent for participating in the study. 5.Patients with tumor of any estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status by immunochemistry (IHC). Patients who have HER2 IHC 2+ tumor will be included, if in situ hybridisation (ISH) for HER2 amplification has or can be been performed. 6. Patients with bilateral cancer. Such cases would be considered as two separate tumors (if both samples are available). 7. Patients with contralateral cancer (Sample would be considered as new tumor). 8.Patients who have newly diagnosed treatment naïve breast cancer (tumor biopsy from primary or metastatic tumor) OR who have received neoadjuvant/adjuvant chemotherapy and/or endocrine therapy (sample from primary tumor)
Exclusion criteria
Exclusion criteria: 1.Patients who are not of Indian origin/ethnicity 2.Patients, who are unwilling to provide informed consent for participating in the study. 3.Patients who, in the opinion of the investigator, are not reliable for follow up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To establish the molecular characterization of breast cancer tumors of all subtypes in a prospective cohort of Indian patients using multi-omic technologies.Timepoint: 60 months, post target sample collection | — |
Secondary
| Measure | Time frame |
|---|---|
| To establish the mutational profile, gene expression pattern, copy number characterization, genome-wide epigenetic modification pattern, proteomic characterization and immune pro-filing in tumors from patients with newly diagnosed, previously untreated breast cancer of all receptor subtypes and pathological subtypes.Timepoint: 5 years, post target sample collection | — |
Countries
India
Contacts
Public ContactYogesh Kembhavi
Tata Memorial Centre
Outcome results
None listed