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Comparing the effects of two different anesthetic agents (Propofol and Sevoflurane) on the blood flow and oxygen concentration in the brain with patients lying face down

Assessment of cerebral blood flow and oxygenation during Propofol versus Sevoflurane based anaesthesia in prone position

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045560
Enrollment
72
Registered
2022-09-15
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: G952- Other and unspecified cord compression

Interventions

Control Intervention1: PROPOFOL: Intravenous Propofol will be used to maintain depth of anesthesia to titrate patient state index between 25 - 50 Control Intervention2: SEVOFLURANE group: SEVOFLURANE

Sponsors

DR GEETHA L
Lead Sponsor
DR JAYA HASITA
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 ââ?¬â?? 65 years 2.ASA 1 and 2 3.Elective thoracolumbar spinal surgeries

Exclusion criteria

Exclusion criteria: 1. Unable to insonate the MCA 2. Re exploration procedures 3. Carotid artery disease 4. Presence of intracranial pathology (intracranial space occupying lesions, meningitis, stroke, traumatic brain injury) 5. Intraoperative dye utilization or blood transfusion 6. Intraoperative SSEP and MEP recording

Design outcomes

Primary

MeasureTime frame
1.To compare the cerebral blood flow (MCA velocity and PI using TCD) between Propofol and Sevoflurane based anaesthesia in prone position 2.To compare the cerebral oxygenation (rSO2 using NIRS) between Propofol and Sevoflurane based anaesthesia in prone position Timepoint: The baseline Cerebral Hemodynamics and Oxygenation parameters will be recorded prior to Surgery, Using Transcranial doppler ultrasound (TCD) and Near infra red spectroscopy.After proning post induction of anesthesia recordings shall be taken every 15 minutes for the first 1 hour, then every 30 minutes for next 2 hours and hourly there after. final recordings shall be taken in the recovery room—

Secondary

MeasureTime frame
To assess the outcome in terms of MMSE (Mini Mental State Examination)Timepoint: A baseline in the pre operative area and in the recovery room after extubation—

Countries

India

Contacts

Public ContactDr Geetha L

Ramaiah Medical College and Hospital

geetha4kiran@yahoo.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026