Health Condition 1: O82- Encounter for cesarean delivery without indication Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Preeclampsia patients undergoing cesarean delivery using spinal block: Titrated dose of carbetocin according to sequential allocation design
intravenous at time of metal delivery, dose of 10 to 100 microgram depending on blinded allocation.
Control Intervention1: Normotensive patients undergoing cesarean delivery using spinal block: Titrat
intravenous at time of metal delivery, dose of 10 to 100 microgram depending on blinded allocation.
Sponsors
UCMS and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Non laboring parturients, with singleton pregnancy, and scheduled for cesarean delivery under spinal anesthesia. Will be allocated to either preeclampsia group or normotensive (control) group, depending on presence or absence of the preeclampsia respectively
Exclusion criteria
Exclusion criteria: ASA grade III or more, presence of active labor (defined as cervical dilatation of 4 cm or more), preoperative use of oxytocin, other conditions predisposing to postpartum haemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED90 dose (dose effective in 90% population) for satisfactory uterine tone as judged by the obstetrician.Timepoint: Uterine tone will be assessed to define the outcome, at 2 minutes after carbetocin injection and then followed by every 1 minute till another 3 minutes, and then if reported spontaneously by obstetrician till end of surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects of carbetocin (hypotension, tachycardia, nausea etc)Timepoint: From 2 minutes after carbetocin to end of surgery. | — |
Countries
India
Contacts
Public ContactThamburu S
UCMS and GTB Hospital
Outcome results
None listed