Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Perioperatively iv infusion of Dexmedetomidine will be started at 0./2 mcg/kg/hr and stopped 10 minutes before extubation: Duration of intervention for each group will be 120 minutes De
Sponsors
Department of Anaesthesiology
Department of General Surgery
Eligibility
Inclusion criteria
Inclusion criteria: Patients giving written informed consent will be taken. Aged between 50-75years. ASA physiological I and II.
Exclusion criteria
Exclusion criteria: Refusal of patients Patients undergone General anesthesia within 7 days, had taken Alpha-2 agonist within 14 days. Patients who had experienced acute stable angina or myocardial infarcation within previous 6 week. Patients with liver cirrhosis, thrombocytopenia and coagulopathies ,third degree heart block and who had contraindication of neuraxial block, severe bradycardia and has systolic blood pressure less than 90 mmhg. Pregnant female Current psychiatric disorder h/o seizures Known drug allergy to the study. ASA III and ASA IV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of dexmedetomidine infusion on post-operative cognitive dysfunction in elderly patients following oral cancer surgery.Timepoint: 48 hrs to 72hrs | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the sedative and analgesic effect of Dexmedetomidine after oral cancer surgeries ââ??ª To compare the post-operative requirement of opioid in patients in both groups. ââ??ª To correlate the ADRA2A genotype with the effect of dexmedetomidine infusion on post-operative cognitive dysfunction. ââ??ª To compare the intra-operative hemodynamic changes in both groups. ââ??ª To assess the post-operative recovery status. ââ??ª Number of days in the ICU and the length of hospital stay after surgery.Timepoint: 48hrs | — |
Countries
India
Contacts
Public ContactProf Rajni Gupta
king george medical college
Outcome results
None listed