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A clinical trial to study the effects of genicular artery embolization, in which the blood vessels supplying the diseased knee are blocked using a minimally invasive angiography-based technique, and compare it with standard therapy, in the patients suffering from osteoarthritis of the knee

Genicular artery embolization for the management of osteoarthritis of the knee: A prospective randomized study - GAEMOK

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045508
Enrollment
50
Registered
2022-09-14
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Genicular artery embolization: After femoral artery puncture and insertion of a vascular sheath, the diseased knee shall undergo DSA which will provide anatomic vascular roadmap for inf

Sponsors

All India Institute of Medical Sciences Patna
Lead Sponsor
All India Institute of Medical Sciences Patna
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Radiographically proven knee osteoarthritis in either sex of age more than 18 years with any radiological grade Patients not responding to conservative management after 6 weeks of initial diagnosis of osteoarthritis on radiographs Patients deemed unfit for surgery or unwilling for surgery for knee osteoarthritis

Exclusion criteria

Exclusion criteria: Poor general condition precluding digital subtraction angiography and embolization under local anesthesia for approximately 2 hours duration Prior surgery in the knee joint Intra-articular injections (steroid, platelet rich plasma or hyaluronic acid, or any such therapy) within 6 weeks of the enrollment in the trial Current or prior infection or trauma to the knee Life expectancy less than 6 months Known advanced atherosclerosis (plaque that builds within the vessels that lead blood to the heart) Rheumatoid or infectious arthritis Iodine allergy Kidney disease

Design outcomes

Primary

MeasureTime frame
Improvement in VAS and KOOS scoresTimepoint: 1 day, 7 days, 30 days, 90 days and 120 days—

Secondary

MeasureTime frame
Change in WORMS score on MRITimepoint: 6 months;Complications such Allergy, Anaphylaxis, Renal failure, hematoma, gangrene, arteriovenous fistula, skin erythema (most common), skin necrosis and ulceration, joint pain, bone necrosis, nausea and vomiting, focal neurological deficitsTimepoint: 1 day, 7 days, 30 days, 90 days and 120 days;Technical success in performing the genicular artery embolizationTimepoint: Immediate—

Countries

India

Contacts

Public ContactSubhash Kumar

All India Institute of Medical Sciences Patna

drsubhash.dm@gmail.com8676836533

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026