Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Fixed dose intravenous infusion of dexmedetomidine: Inj. Dexmedetomidine is started with bolus dose 1�mcg/kg and followed by infusion (0.5 mcg/kg/hr) before activation of propofo
Sponsors
Vijaynagar institute of medical sciences
Eligibility
Inclusion criteria
Inclusion criteria: American society of Anaesthesiologists physical status 1 to 2 Non obese(BMI 18.5 to 29)
Exclusion criteria
Exclusion criteria: Refusal of patient consent Patients with significant systemic diseases Patients on long term and concurrent sedative intake
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stability of haemodynamic parameters during laparoscopy (with changes in mean arterial pressure as primary objective)Timepoint: 1)on arrival to operating room,2)after bolus doses of test drugs,3)pre induction,4)post intubation (1 min, 2min, 5min,10min),5)at initiation of pneumo insufflation, 6)post pneumo- insufflation, 7)every 5ââ?¬â?°minutes till end of procedure;8)after removal of trocar, 9)stop of propofol infusion , 10)administration of reversal, 11)at extubation, 12)1 min, 2min, 5min and10min following extubation till shift out to Post anesthesia care unit (PACU) | — |
Secondary
| Measure | Time frame |
|---|---|
| correlation of TCI propofol with the state entropy levels i.e the effecctor site concentration value of propofol and corresponding state entropy valuesTimepoint: Effector site concentration of propofol and corresponding state entropy values measured on 1)shifting in ot,2)after bolus doses of test drugs, 3)pre induction, 4)at intubation 5)following intubation at(1 min, 2min, 5min,10min),6) initiation and end of pneumo insufflation, and 7)every 5minutes till end of procedure,8)removal of trocar, 9)stop of propofol infusion, 10)administration of reversal, 11) extubation, 12)1 min, 2min, 5min and10min following extubation ;Postop nausea and vomiting assesment in PACU and postop wards by PONV Impact scale (4 point likert scale) along with vomiting countsTimepoint: IN PACU AND postop wards,every 2nd hourly for 24 hours;total propofol dose usedTimepoint: at the end of surgery | — |
Countries
India
Contacts
Public ContactDr Bala Bhaskar S
Vijaynagar institute of medical sciences
Outcome results
None listed