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Effect of dexmedetomidine given through nebulisation by mask from nasal route before operation on stress response to laryngoscopy during general anesthesisa.

Efficacy of two different doses of nebulised dexmedetomidine for attenuation of hemodynamic response to laryngoscopy and intubation - A randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045333
Enrollment
90
Registered
2022-09-08
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulised Dexmedetomidine: 1.Group A (DA) ââ?¬â?? will receive pre-operative nebulisation with 1 mcg/kg of dexmedetomidine diluted with 0.9% NS to 5 mL. 2.Group B (DB

Sponsors

Dr Soumya Ranjan Sahoo
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient posted for elective surgeries under general anesthesia with ET tube. 2. American Society of Anesthesiologists (ASA) physical status I and II. 3. Age: 18 ââ?¬â?? 60 Years.

Exclusion criteria

Exclusion criteria: 1) Predicted difficult airway. 2) Subjects requiring more than 15 secs or 2 attempts at laryngoscopy. 3) Obese patients (BMI >30). 4) Subjects on antihypertensive medication. 5) Pregnancy 6) seizure disorder 7) Known allergy to dexmedetomidine 8) Renal failure 9) Poor cardiopulmonary reserve

Design outcomes

Primary

MeasureTime frame
SBP(mmHg) at 1 minute after intubation. Timepoint: 1 minute.—

Secondary

MeasureTime frame
1) SBP(mmHg) at 3,5 and 10 minutes after intubation. 2) DBP(mmHg), MAP(mmHg) , HR (bpm) at 1,3,5 and 10 minutes after intubation. 3) Induction dose of propofol (mg) 4) Incidence of sore throat, post operative nausea and vomiting up to 24 hours Timepoint: 1,3,5,10 minutes post intubation till 24 hours post intubation—

Countries

India

Contacts

Public ContactDr Soumya Ranjan Sahoo

Kalinga Institute Of Medical Sciences

amit.pradhan@kims.ac.in9437191002

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026