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Comparing two methods of giving oxygen during anesthesia i.e. High Flow nasal Oxygen or routinely done bag-mask ventilation in patients with difficult mask ventilation.

Comparison of high flow nasal oxygen vs conventional bag mask ventilation for preoxygenation and apnoeic oxygenation in adults with difficult mask ventilation under general anaesthesia: an open labelled randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045294
Enrollment
72
Registered
2022-09-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs

Interventions

Intervention1: High flow nasal oxygen: Preoxygenation and apneic oxygenation with high flow nasal oxygen. HFNO group will receive 100% oxygen and flow 30L/min for 3 minutes via high flow nasal canula.

Sponsors

All India Institute Of Medical SciencesAIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All ASA I &II aged 18-65 Years posted for general anaesthesia who are anticipated difficult airway comprising of the following a) Patients with BMI >25 b) Absence of teeth c) History of snoring d) Bearded patient e) Mallampati grade III and IV f) Severely limited mandibular protrusion g) Face and neck deformities due to prior surgery, prior trauma, congenital abnormalities h) Previous and current cervical spine injuries i) Patients with rheumatoid arthritis, scleroderma j) Patients with oropharyngeal cancers 2. Consent for participation

Exclusion criteria

Exclusion criteria: 1. Pregnant females 2. Patients having cardiorespiratory pathologies 3. Patients who are planned for rapid sequence induction

Design outcomes

Primary

MeasureTime frame
The primary objective is to assess the difference in partial pressure of oxygen, after 3 min of preoxygenation in patients preoxygenated with HFNO vs patients preoxygenated with bag mask ventilationTimepoint: The difference in partial pressure of oxygen will be noted by taking arterial blood sample after three minutes of pre oxygenation—

Secondary

MeasureTime frame
1. Difference in partial pressure of oxygen.Timepoint: After intubation;2. Difference in end tidal O2Timepoint: After intubation;3. Incidence of hypoxemic events(SpO2 92%)Timepoint: Number of Events until intubation;4. Tolerability of high flow nasal canula by patients, i.e., if patients request to reduce flow or feeling of dryness, itching etc.Timepoint: Till induction;5.Time taken to successful intubationTimepoint: After Intubation;6. Any complications until following intubation like arrhythmiasTimepoint: After intubation;7. Reoxygenation time defined as the time taken for SpO2 to return to 100% after mechanical ventilation.Timepoint: After initiation of Mechanical ventilation—

Countries

India

Contacts

Public ContactVanlaltlani Khawlhring

All India Institute of Medical Sciences, Jodhpur,INDIA

docbpali@gmail.com9588089378

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026