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TO STUDY THE EFFECT OF PERIPHERAL NEUROPATHY DUE TO VINCRISTINE ON FUNCTIONS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

EFFECT OF VINCRISTINE INDUCED PERIPHERAL NEUROPATHY ON FUNCTIONAL ABILITIES OF PAEDIATRIC CANCER PATIENTS- A PROSPECTIVE OBSERVATIONAL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/09/045215
Enrollment
94
Registered
2022-09-05
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C910- Acute lymphoblastic leukemia [ALL]

Interventions

None listed

Sponsors

Manjusha Vagal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: (1) Patient diagnosed with Acute lymphoblastic leukaemia. (2) Patient willing to take entire treatment at Tata memorial hospital. (3) Patient willing to follow-up for periodic assessments at Tata Memorial Hospital.

Exclusion criteria

Exclusion criteria: (1) Patients presenting with neurological deficit at baseline assessment. (2) Pre-morbid neuromuscular disorders (such as traumatic brain injury or cerebral palsy) (3) Childhood diabetes mellitus induced peripheral neuropathy. (4) Paediatric cancer patients other than Acute Lymphoblastic Leukaemia (5) Patients unable to complete

Design outcomes

Primary

MeasureTime frame
1. To understand the incidence, of sensory and motor symptoms in Acute Lymphoblastic Leukaemia patients receiving chemotherapy involving vincristine. 2. To understand the course of presentation of sensory and motor symptoms in Acute Lymphoblastic Leukaemia patients receiving chemotherapy involving vincristine Timepoint: 1 Baseline assessment followed by weekly assessments during induction phase of administration of vincristine and then monthly assessments until completion of intensive phase of chemotherapy as per protocol

Secondary

MeasureTime frame
3. To examine and record impact of vincristine on Function using Canadian occupational performance measure 4. To examine and record impact of vincristine on Play participation using Takata play history 5. To examine and record impact of vincristine on Schooling abilities using a departmental semi-structured interview Timepoint: 1 Baseline assessment followed by weekly assessments during induction phase of administration of vincristine and then monthly assessments until completion of intensive phase of chemotherapy as per protocol

Countries

India

Contacts

Public ContactSaumya Dixit

Tata Memorial Hospital

vagalmanjusha@yahoo.com9867552266

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026