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Comparison of a gum graft and a dressing processed from animal skin for treatment of receded gums.

Comparison of the outcomes of using connective tissue graft versus volume-stable collagen matrix with modified coronally advanced flap for the treatment of multiple adjacent gingival recessions: A randomized clinical trial with molecular analysis�

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/09/045149
Enrollment
28
Registered
2022-09-01
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Volume stable collagen matrix: The volume stable collagen matrix device will be sutured at the surgical site for root coverage and left in place, and covered with overlying modified cor

Sponsors

Indian Council of Medical Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a) systemically healthy individuals b) Healthy periodontium or demonstrating stable periodontal condition following conventional periodontal therapy c) Full mouth plaque score (FMPS) and full mouth bleeding score (FMBS) of d) No history of previous periodontal surgery at experimental sites e) Presence of at least two adjacent Cairo RT1 (gingival recession with no loss of interproximal attachment) multiple buccal recessions � 2 mm on anterior teeth or premolars in both jaws f) Presence of an identifiable CEJ (a step �1 mm at CEJ level and/or presence of a root abrasion, but with an identifiable CEJ, will be accepted). g) Probing depth (PD) � 3 mm h) Absence of non-vital, supraerupted or mobile teeth for treatment of gingival recession

Exclusion criteria

Exclusion criteria: a) Molars and teeth with presence of restorations, caries or crowns in the area to be treated. b) Gingival recessions presenting minimal amount ( c) Pregnant and lactating females d) Smokers or tobacco usage in any form e) History of any systemic medication in last 3 months f) Patients with coagulation disorders

Design outcomes

Primary

MeasureTime frame
To compare and evaluate effectiveness of connective tissue graft and volume-stable collagen matrix with modified coronally advanced flap procedure in terms of gingival recession depth reduction and soft tissue thickness gain after either treatment.Timepoint: Baseline, 1 month, 3 months, 6 months—

Secondary

MeasureTime frame
Objective assessment of aesthetic outcome using root coverage esthetic score (RES) To assess any differences in patient- centered outcome in terms of postsurgical pain till 1 week and dentinal hypersensitivity and aesthetic satisfaction.Timepoint: Baseline, 3 months, 6 months;To assess revascularization and wound healing dynamics through expression of specific biomarkers in GCFTimepoint: Baseline (prior to surgery), and at 7, 14, 28, 90 and 180 days after the treatment—

Countries

India

Contacts

Public ContactVikender Singh

All India Institute of Medical Sciences

vikenderyadav@gmail.com8800798248

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026