Health Condition 1: I998- Other disorder of circulatory system
Conditions
Interventions
Intervention1: 5 mL/kg: Administration of the first fluid bolus will be at a volume of 5 mL/kg per bolus over 5-10 minutes in hypotensive shock and over 20-30 minutes in compensated shock will be give
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: All children 2 months to less than 17 years of age admitted to the emergency/ICU with a diagnosis of septic shock will be eligible for inclusion. At least 3 of the following criteria should be present of which criteria no.1 is essential criteria – 1) capillary refill time 2 seconds or less than 1 second, 2) cold extremities 3) feeble or bounding peripheral pulses 4) hypotension (systolic BP less than 5th centile as per PALS guidelines) and 5) history of decreased urine output
Exclusion criteria
Exclusion criteria: 1.Children who received boluses before enrolment 2. Children with chronic kidney disease / fulminant myocarditis / dengue shock syndrome / 3. Children with severe anemia (Hb 4. Post-arrest shock and cardiac dysfunction 5. Moribund patients with anticipated survival of
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change in mottling score before and after 15 minutes of the bolus and reassessed at 1 hour and 6 hours of fluid resuscitation. 2. Change in surface temperature gradient between centre to periphery before and after 15 minutes of the bolus and reassessed at 1 hour and 6 hours of fluid resuscitation. 3. Change in biomarkers of endothelial dysfunction will be assessed at baseline, after 1 hour of the first bolus and at 6 hours and 24 hours of fluid resuscitation.Timepoint: At baseline and after 15 minutes of the first bolus, at 1 hour and 6 hours of enrolment | — |
Secondary
| Measure | Time frame |
|---|---|
| The agreement between the macrocirculation and the microcirculationTimepoint: Will be assessed after 15 minutes of the first fluid bolus and repeated at 1 hour and 6 hours of resuscitation. | — |
Countries
India
Contacts
Public ContactJhuma sankar
AIIMS
Outcome results
None listed