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use of drugs to maintain blood pressure during anaesthesia

Evaluation of the efficacy of intravenous ondansetron in comparison to ondansetron with dexamethasone for prevention of spinal anaesthesia induced hypotension in patients posted for infraumbilical surgeries –A prospective, randomised double blind study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/045046
Enrollment
120
Registered
2022-08-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 3: N43- Hydrocele and spermatocele Health Condition 4: I83- Varicose veins of lower extremities

Interventions

Intervention1: intravenous ondansetron before spinal anesthesia: patients in either group will receive intravenous ondansetron or ondansetron and dexamethasone prior to spinal anesthesia Control Inter

Sponsors

ESIC MEDICAL COLLEGE HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II patients posted for infra umbilical surgeries Age 18 – 60 years

Exclusion criteria

Exclusion criteria: ASA III and IV patients. patient refusal Known allergies to Ondansetron, dexamethasone QTc > 400msecs Patients with autonomic neuropathy Parturients

Design outcomes

Primary

MeasureTime frame
compare the efficacy of intravenous ondansetron versus ondansetron with dexamethasone to prevent hypotension and bradycardia after spinal anaesthesia.Timepoint: at 3rd, 6th,9th,12th,15th,20th,25th,30th,35th,40th,45th,50th,55th and 60th minute after spinal anaesthesia—

Secondary

MeasureTime frame
To compare incidence of nausea, vomiting, shivering, time for two segment regression of sensory block, time to rescue analgesia and adverse effect of study drugTimepoint: baseline, at 4 hours and at 24 hour—

Countries

India

Contacts

Public ContactAnanya nanda

ESIC MEDICAL COLLEGE HOSPITAL

nanda.ananya@gmail.com08179654082

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026