Health Condition 1: H168- Other keratitis
Conditions
Interventions
Intervention1: Hyper-CLâ?¢ lens with Reducing loading dose of topical Antibiotics(Reduced treatment burden): Treatment Group 1 (Reduced treatment burden): Reducing loading dose in the first hour, foll
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: 1.Subject is 18-86 years old 2.Subject with Bacterial keratitis in one eye only 3.Subject with Bacterial Keratitis infiltrate of at least 1.5 mm in diameter 4.Subjects with no prior antibiotic treatment or treatment up to 12 hours prior enrolment. 5.Subject understands the study requirements and the treatment procedures and provides written Informed Consent before any study-specific tests or procedures are performed.
Exclusion criteria
Exclusion criteria: 1.Perforation 2.Subject with elevated bleb (glaucoma shunts) 3.Sign of inflammation in both eyes 4.Severe itching suggesting viral infection or allergy reaction 5.Subepithelial infiltrate suggesting viral infection 6.Dendrite like ulcer or suspecting of Herpes keratitis 7.Previous penetrating keratoplasty 8.Pregnancy 9.Any infiltration suggesting other than bacterial infection e.g., parasite, fungal. 10.Post refractive surgery 11.Corneal inlays 12.Subject with neuropathic corneas 13.Subjects with Chronic autoimmune diseases 14.Any other condition which in the opinion of the investigator would place the patient at undue risk for participation. 15.Participation in another clinical study within the past 30 days 16.Patient requires different treatment regimen then determined by the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in average diameter of epithelial defect over timeTimepoint: up to 14 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline in Pain score over timeTimepoint: up to 14 days;Change in Bacterial Keratitis severity at day 3Timepoint: up to 14 days;Change in cell in AC over timeTimepoint: up to 14 days;Change in Visual Acuity over timeTimepoint: up to 14 days;Time for significant improvement in Bacterial Keratitis severity - 50% reduction in epithelial defect.Timepoint: up to 14 days | — |
Countries
India
Contacts
Public ContactProf A Heber
Dr. Agarwals Eye Hospital
Outcome results
None listed