Holmium Laser en-bloc Resection Vs Bipolar Transurethral Resection for Bladder Cancer Management

Comparison of Clinicopathological Outcomes in Holmium Laser en-bloc Resection of Bladder Tumor Vs Bipolar Transurethral Resection of Bladder Tumor- A Prospective Non-Randomized Observational Trial.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/08/045042

Enrollment

Registered

2022-08-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C679- Malignant neoplasm of bladder, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Holmium Laser en-bloc Resection of Bladder Tumor: Patients with bladder tumor shall undergo Holmium Laser en-bloc Resection of Bladder Tumor. This is a method of bladder tumor resection

Eligibility

Inclusion criteria

Inclusion criteria: All consented preoperative cases of bladder tumors detected on ultrasound, CT or MRI imaging visiting AIIMS Bhubaneswar for further management.

Exclusion criteria

Exclusion criteria: a. Patients who do not give consent. b. Patients unfit for surgery. c. Recurrent bladder tumors d. Patients who received prior intravesical therapy e. Tumors > 4 cm in size f. Tumors > 4 in number

Design outcomes

Primary

Measure	Time frame
To compare the incidence of thermal artifacts amongst Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder Tumor specimens.Timepoint: 2 weeks after surgery	—

Secondary

Measure	Time frame
To compare intraoperative clinical outcomes: operative time, irrigation volume, bladder perforation, obturator jerk amongst patients undergoing Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder TumorTimepoint: 2 weeks after surgery;To compare postoperative clinical outcomes: catheterization time, clot retention irritative symptoms amongst patients undergoing Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder Tumor.Timepoint: Immediately after surgery- first 1 week;To determine circumferential resection margin and deep resection margin negativity rate in Holmium Laser en-bloc Resection of Bladder Tumor specimens.Timepoint: 2 weeks after surgery;To determine detection rate of muscularis mucosa, muscularis propria and ability to sub stage T1 disease amongst Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder Tumor specimensTimepoint: 2 weeks after surgery	—

Measure

Time frame

To compare intraoperative clinical outcomes: operative time, irrigation volume, bladder perforation, obturator jerk amongst patients undergoing Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder TumorTimepoint: 2 weeks after surgery;To compare postoperative clinical outcomes: catheterization time, clot retention irritative symptoms amongst patients undergoing Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder Tumor.Timepoint: Immediately after surgery- first 1 week;To determine circumferential resection margin and deep resection margin negativity rate in Holmium Laser en-bloc Resection of Bladder Tumor specimens.Timepoint: 2 weeks after surgery;To determine detection rate of muscularis mucosa, muscularis propria and ability to sub stage T1 disease amongst Holmium Laser en-bloc Resection of Bladder Tumor and Bipolar Transurethral Resection of Bladder Tumor specimensTimepoint: 2 weeks after surgery

—

Countries

India

Contacts

Public ContactDr Vivek Tarigopula

All India Institute of Medical Sciences, Bhubaneswar

urol_swarnendu@aiimsbhubaneswar.edu.in8297748337

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 6, 2026