Health Condition 1: - Health Condition 2: I998- Other disorder of circulatory system
Conditions
Interventions
Intervention1: Adding vaso active agents: Norepinephrine
Control Intervention1: Epinephrine: 0.1mg/kg ,intravenously,15 mins , can be titration upto 0.3mg/kg every 15 mins
Control Intervention2: Addin
Sponsors
Dr JANARTHANAN A
Eligibility
Inclusion criteria
Inclusion criteria: All the patients admitting in Paediatric emergency and pediatric intensive care unit ,AIIMS Patna , having signs and symptoms at presentation suggestive of septic shock as defined above & patients admitted in pediatric ward, later developing signs and symptoms of septic shock as per inclusion criteria. Age minimum : 1 month Age maximum : 15 years
Exclusion criteria
Exclusion criteria: Exclusion criteria : 1. Patients requiring CPR at presentation. 2. Patients with fluid responsive shock not requiring any vasoactive agent. 3. Patients with known cardiac disease requiring any specific vasoactive agent such as dobutamine and milrinone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resolution of shock is defined as a.Normalisation of heart rate (age and sex adjusted). b.Capillary refilling time less than 3 secs. c.Systolic and diastolic pressure above 5th percentiles. d.Improving urine output (more than 0.5 – 1 ml/kg/hr). Improving blood lactate levels (if initial levels elevated).Timepoint: at 15 mins,30 mins ,45 mins | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare time taken for resolution of septic shock between two groups. To compare 28 days survival outcome between two groups.Timepoint: 30 mins vs 60 mins | — |
Countries
India
Contacts
Public ContactJANARTHANAN A
AIIMS PATNA
Outcome results
None listed