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Nebulization of different doses of ketamine prior to surgery decreases incidence of sore throat in post operative period following endotracheal intubation

Effect of Preoperative Nebulized Ketamine on the Incidence and Severity of Postoperative Sore Throat Following Endotracheal Intubation: A Randomized Controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/045007
Enrollment
60
Registered
2022-08-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ketamine: Patients undergoing elective surgery under general anaesthesia with endotracheal intubation are subjected to nebulization of ketamine in two different doses of 50mg and 25mg a

Sponsors

Ashvinth Saravanan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of age group between 18 and 60 years American Society of Anaesthesiologists physical status I and II Patients with Modified Mallampati Grade I and II Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation in supine position lasting upto 2 hours

Exclusion criteria

Exclusion criteria: Patients undergoing emergency surgery. Patients who are unable to give consent. Patients with contraindication to general anaesthesia. Patients with H/o preoperative sore throat, upper respiratory tract infection, bronchial asthma, Chronic Obstructive Pulmonary Disease (COPD). Patients with known allergy to study drug. Pregnant patients Chronic smokers Patients undergoing oral, nasal, head and neck surgeries

Design outcomes

Primary

MeasureTime frame
To determine the efficacy of different doses of nebulized ketamine in alleviating the incidence and severity of Postoperative sore throat in patients receiving GA with endotracheal intubationTimepoint: Baseline, 2 hours, 6 hours, 8 hours, 12 hours, 16 hours and 24 hours after extubation—

Secondary

MeasureTime frame
To look for side effects of nebulized ketamine in the postoperative period 24 hours following extubationTimepoint: Baseline, 2 hours, 6 hours, 8 hours, 12 hours, 16 hours and 24 hours after extubation—

Countries

India

Contacts

Public ContactAshvinth Saravanan T

Jawaharlal Nehru Medical College

vandanagogate@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026