Health Condition 1: E282- Polycystic ovarian syndrome
Conditions
Interventions
Intervention1: Vitamin E: 200 mg OD for group 2 and 400 mg OD for group 3 for 3 months
Control Intervention1: Drospirenone with ethinyl estradiol: 3mg drospirenone with 20mcg ethinyl estradiol OD for
Sponsors
SRM institute of Science and Technology
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed with polycystic ovarian syndrome according to Rotterdam criteria and did not use any injectable or implant or hormonal contraceptives within 6 months or oral contraception and IUD within 3 months before the study will be included.
Exclusion criteria
Exclusion criteria: Women who were pregnant, want to get pregnant or suspected of being pregnant, breastfeeding women, contraindicated for using COCs, diagnosed with concomitant hyperthyroidism, Hyperprolactinemia, diabetes mellitus, renal, or adrenal insufficiency will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drospirenone and ethinyl estradiol with vitamin E supplements may be better than drospirenone and ethinyl estradiol in relation with oxidative stress as well as hormone balance. Adolescents administered with vitamin E can have regular cycles with improvement in acne and hirsutism like symptoms.Timepoint: Total testosterone, and follicle stimulating hormone (FSH) and insulin resistance by Homa- IR, Total Antioxidant Capacity (TAC), Glutathione (GSH). | — |
Secondary
| Measure | Time frame |
|---|---|
| Hirsutism and acne may be improved in adults as well as adolescents.Timepoint: Acne and Hirsutism. | — |
Countries
India
Contacts
Public ContactDr M Sumithra
Department of Obstetrics and Gynecology, SRM Medical College Hospital and Research Centre
Outcome results
None listed