FindTrial
Sign In

To study effect of two doses of iv clonidine on vital parameters, when given as a premedication in laparoscopic cholecystectomy under general anaesthesia.

Comparison between hemodynamic changes of two different doses of intravenous clonidine as premedication in laproscopic cholecystectomy under general anaesthesia: a randomized, double blind, interventional, study at sms hospital jaipur( 2021-23)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/045000
Enrollment
154
Registered
2022-08-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj clonidine 1mcg/kg: Inj clonidine 1mcg/kg given 30min before induction of anaesthesia Control Intervention1: inj clonidine 2mcg/kg: Inj clonidine 2mcg/kg given 30min before induction

Sponsors

Sms medical college jaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient willing to give written informed consent 2.age 18 years to 45years of both sex. 3.ASA grade 1 and 2 4.Weight 40-80kg 5.Planned for elective laparoscopic cholecystectomy under general anaesthesia

Exclusion criteria

Exclusion criteria: 1.History of allergy to clonidine 2.Anticipated difficult intubation 3.History of consumption of antihypertensive drugs, sedative, hypnotics and antidepressants preoperatively. 4.History of cardiovascular disease,significant respiratory,renal and hepatic disorder. 5.History of drugs or alcohol abuse. Pregnant women.

Design outcomes

Primary

MeasureTime frame
To determine the proportion of difference in changes in haemodynamic responses( Heart Rate,Systolic BP,Diastolic BP,Mean arterial Pressure) from baseline to different time interval in the both group.Timepoint: 1.just before giving IV clonidine(as baseline). 2.15 min after premedication. 3. 30 min after premeditation. 4. After intubation. 5. Start of creating pneumoperitoneum. 6. 5 min after creating pneumoperitoneum. 7. 10min after creating pneumoperitoneum. 8.15 min after creating pneumoperitoneum. 9. 30min after creating pneumoperitoneum. 10. Release of pneumoperitoneum. 11. After extubation.—

Secondary

MeasureTime frame
to determine the difference in percentage in cases who develop side effect in first 24hrs in both groupTimepoint: any time in first 24hrs—

Countries

India

Contacts

Public ContactDr Meena Bhupendra Murarilal

Sawai mansingh medical college and hospital,jaipur

rajesh_sms@hotmail.com9414078285

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026