A clinical study to compare between intravenous dexmedetomidine and intravenous lignocaine in decreasing the hemodynamic responses to laryngoscopy and tracheal intubation.

Comparative efficacy of iv dexmedetomidine and iv lignocaine in attenuation of hemodynamic response to laryngoscopy and tracheal intubation : Randomized control study - Dexmedetomidine, lignocaine

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/08/044986

Enrollment

Registered

2022-08-26

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs Health Condition 2: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: Injection Dexmedetomidine 0.5 microgram iv: 0.5 microgram per kg dexmedetomidine to be given iv in 100 ml NS over 10 minutes before intubation Control Intervention1: Injection Lignocain

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 18 to 60 years 2. American Society of Anaesthesiologists physical status 1 and 2 3. Who has given written and informed consent

Exclusion criteria

Exclusion criteria: 1. Who has not given written informed consent 2. Patients with heart rate less than 60 per minute 3. Patients with anticipated difficult intubation 4. Patients with systolic blood pressure less than 100 mmHg 5. Patients with history of cardiac , renal, cerebral, peripheral vascular disease, obesity , pregnant woman and nursing mothers 6. History suggestive of sensitivity to drugs used in the study 7. Intubation attempts lasting more than 30 seconds

Design outcomes

Primary

Measure	Time frame
To measure changes in Heart rate, Systolic blood pressure , Diastolic blood pressure Mean arterial pressure after injection of iv Dexmedetomidine and iv Lignocaine To study sedation till one hour post surgery To study post operative nausea and vomiting till one hour after surgeryTimepoint: To measure changes in Heart rate, Systolic blood pressure , Diastolic blood pressure Mean arterial pressure after injection of iv Dexmedetomidine or iv Lignocaine at baseline , just before intubation , at the time of intubation, at 1 minute, at 3 minute, at 5 minute and at 10 minute following intubation To study sedation till one hour post surgery To study nausea vomiting till one hour post surgery	—

Measure

Time frame

To measure changes in Heart rate, Systolic blood pressure , Diastolic blood pressure Mean arterial pressure after injection of iv Dexmedetomidine and iv Lignocaine To study sedation till one hour post surgery To study post operative nausea and vomiting till one hour after surgeryTimepoint: To measure changes in Heart rate, Systolic blood pressure , Diastolic blood pressure Mean arterial pressure after injection of iv Dexmedetomidine or iv Lignocaine at baseline , just before intubation , at the time of intubation, at 1 minute, at 3 minute, at 5 minute and at 10 minute following intubation To study sedation till one hour post surgery To study nausea vomiting till one hour post surgery

—

Secondary

Measure	Time frame
1.Post op sedation score at the time of extubating the patient 2. Post op nausea and vomiting at extubationTimepoint: Immediate post op at the time of extubation	—

Countries

India

Contacts

Public ContactDr Pranab Kalita

Gauhati Medical College And Hospital

11980pran@gmail.com7002181200

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026