FindTrial
Sign In

A drug (ONDANSETRON), used in treatment of vomiting, has been shown to prevent fall in blood pressure after spinal anesthesia. This study identifies efficacy of ONDANSETRON in preventing fall in blood pressure after spinal anesthesia in pregnant women coming for cesarean operation.

EFFICACY OF ONDANSETRON IN PREVENTING SPINAL ANAESTHESIA INDUCED HYPOTENSION IN LOWER SEGMENT CESAREAN SECTION (LSCS) PATIENTS ; A RANDOMISED CONTROL STUDY

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/044985
Enrollment
50
Registered
2022-08-26
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: 1- Obstetrics

Interventions

Intervention1: Ondansetron: Patients randomized and fulfilling all criteria will have their vitals and demographic data recorded. Baseline (t0) measurements of SpO2, perfusion index (PI), SBP, DBP, MA
patients who failed to reach at least this level will be excluded from the study, and general anesthesia will then be administered at the attending anesthesiologistâ??s discretion. All hemodynamic pa

Sponsors

Saveetha Medical College Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status II 2. Elective LSCS under Spinal anaesthesia 3. Hemodynamically stable 4. Full term, singleton pregnancy

Exclusion criteria

Exclusion criteria: 1. Patients with prolonged Qtc >450ms 2. Patients with bradycardia (heart rate 3. Morbid obese 4. Patients with pre-existing cardiac disease 5. Patients with liver and renal dysfunctions 6. History of hypertension, pre-eclampsia, and convulsions 7. Patient with bleeding disorders 8. Uterine abnormality â?? placenta previa, abruptio placenta 9. Multiple gestation pregnancy 10. Patient refusal 11. Unstable hemodynamics 12. Coagulation abnormalities 13. Study drug allergy

Design outcomes

Primary

MeasureTime frame
Reduced incidence of spinal induced hypotension and its associated complications in ondansetron group.Timepoint: Post-spinal anesthesia and intraoperatively during LSCS procedure.—

Secondary

MeasureTime frame
Reduced incidence of spinal induced hypotension in patients with predictors (PI 3.5) of possible spinal induced hypotension in ondansetron group.Timepoint: Post-spinal anesthesia and intraoperatively during LSCS procedure.—

Countries

India

Contacts

Public ContactBeulah Shekinah Elango

Saveetha Medical College and Hospital

dr.beulah.bse@gmail.com8072535406

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026