Health Condition 1: G02- Meningitis in other infectious andparasitic diseases classified elsewhere
Conditions
Interventions
Intervention1: Drug Pentoxifylline: Tab Pentoxifylline at 20 mg/kg/day divided into 3 doses for 3 days (tablet to be crushed and mix with water and to be given through nasogastric tube).
Control Inter
Sponsors
All India Institute of Medical Sciences Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: Children between 1 month and 14 years of age admitted to the IPD and PICU, dept. of paediatrics, All India institute of medical sciences, Bhubaneswar during the study period if they satisfy case definition of AES as per NVBDCP(national vector Borne disease control programme)guideline of India and have baseline GCS of � 12
Exclusion criteria
Exclusion criteria: 1. Duration of illness > 14 days at presentation 2. Known bleeding disorder 3. Vasculitis 4. Cerebral hemorrhage 5. Retinal Hemorrhage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Time (hours) required to attain normal GCS or improvement by score of 3 as per pediatric GCS for ââ?°Â¤ 2 years, and standard GCS for 2-14 years old child after initiation of treatment. Timepoint: every 6th hourly GCS will be assessed, starting from the time of 1st dose of intervention/ standard care till attainment of normal GCS or improvement of GCS by 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Adverse effects of Pentoxifylline. 2. Any change in the frequency of common Sequelae of AES (hearing problems, visual disturbance, and motor abnormality)Timepoint: At 1 month and 3 months of discharge | — |
Countries
India
Contacts
Public ContactYATHEESH K S
All India Institute Of medical Sciences, Bhubaneswar
Outcome results
None listed