A Study to evaluate the effectiveness of tramadol injected before wisdom tooth removal in reducing post Lower wisdom tooth extraction pain

Evaluation of the Efficacy of Pre-operative Submucosal Injection of Inj.Tramadol (100mg/2ml) for Post-operative Pain Control in Participants Undergoing Surgical Extraction of Mandibular Third Molar Tooth - A Double Blinded Experimental Randomized Controlled Clinical Study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/08/044922

Enrollment

Registered

2022-08-25

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Injection Tramadol: Single use Pre - extraction injection of Tramadol in 100mg in 2 ml Control Intervention1: Inj. Saline: 2ml submucosal pre- extraction injection of INJ. Saline

Eligibility

Inclusion criteria

Inclusion criteria: Patients more than 18 years of age Participants requiring surgical extractions of third molars in mandibular arch Hypertensive patients with controlled blood pressure (BP Diabetic patients with controlled blood sugar level (HbA1c Participants willing to participate in study

Exclusion criteria

Exclusion criteria: Patients with positive history of substance abuse (alcohol, opiates, etc.) Patients who have consumed alcohol in the past 48 hours. Participants with history of cardiac surgeries, uncontrolled hypertension, uncontrolled diabetes, patients on anti-epileptic therapy, patients on medication for psychiatric illness (SSRIs, MAOs). Participants who are already participating in another study.

Design outcomes

Primary

Measure	Time frame
PainTimepoint: measured by at 60,90,120,150,180, 240 minutes post operative period	—

Secondary

Measure	Time frame
No. Of rescue analgesicsTimepoint: Within 24 hours;Onset of local anaesthesiaTimepoint: No. Of minutes after injecting lignocaine;Time of first analgesicTimepoint: Post operative time in minutes	—

Countries

India

Contacts

Public ContactDr Heti Kacha

Nair Hospital Dental College

drnnandrade@gmail.com982112683

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026