Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Melatonin: Tab Melatonin 6mg to be given orally to patients 2 hours prior to surgery
Control Intervention1: Alprazolam: Tab Alprazolam 0.5mg to be given orally to patients 2 hours prio
Sponsors
Sharda Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient undergoing tympanoplasty surgeries under general anaesthesia 2. ASA class I and II
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate in the study 2. Patients receiving steroids, analgesics, antiemetic, sedatives and antipsychotics. 3. Patients having history of endocrine, cardiovascular, renal or CNS disease. 4. Patients allergic to study drugs. 5. BMI > 30 kg m-2 6. Patient having chronic pain and any mental illness 7. Pregnant patients 8. Patients with inability to read and write basic alphabets and numbers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effects of melatonin and alprazolam on preoperative anxiety.Timepoint: 2 hours post surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the effects of melatonin and alprazolam on: (a) Pre-operative sedation (b) Pre-operative cognition 2. To compare the effects of melatonin and alprazolam on: (a) Post-operative sedation (b) Post-operative anxiety (c) Post-operative cognition 3. To compare post operative pain in the two groupsTimepoint: 2 hours post surgery | — |
Countries
India
Contacts
Public ContactDr Harsh Vardhan
School of Medical Science and Research
Outcome results
None listed