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Effect of dexmedetomidine on proinflammatory markers.

Effect of intravenous Dexmedetomidine infusion on Proinflammatory cytokines and Postoperative systemic Inflammatory response syndrome In patients undergoing Elective abdominal surgeries.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/08/044791
Enrollment
50
Registered
2022-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine infusion: Dexmedetomidine will be administered (1â���µg/kg) for 20 min before anaesthesia induction and continue to be infused (0.5â���µg/kg/hour) duri

Sponsors

Multidisciplinary Research Unit Guru Gobind Singh Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of American Society of Anesthesiologists (ASA) Physical Status I, II, III and (4) absence of clinical infections or positive urine culture will be included.

Exclusion criteria

Exclusion criteria: (1) pre-existing heart disorders, (2) long-term use of sedative drugs,steroid (3) fever within one�week (4) undergoing another surgery simultaneously (5) those who failed to be followed up will be excluded.

Design outcomes

Primary

MeasureTime frame
To assess the inflammatory cytokines markers, TNF and IL-6 after dexmedetomidine infusion in patients undergoing elective abdominal surgeries.Timepoint: at baseline (before surgery) and 24 hrs, 48 hrs & 72 hrs after surgery.—

Secondary

MeasureTime frame
To find incidence of postoperative systemic inflammatory response syndrome in patients.Timepoint: 24 hrs, 48 hrs and 72 hrs after surgery.—

Countries

India

Contacts

Public ContactDr Richu Singla

Guru Gobind Singh Medical College, Faridkot, Punjab

drsarvjeet@ggsmch.org9915680508

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026