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To Analyze the Effect of Bone healing in Periapical Defects using L-PRF, Simvastatin, AND amniotic membrane as bone grafts by clinicaly and radiographicaly.

COMPARATIVE EVALUATION OF BONE REGENERATION WITH L-PRF , AMNIOTIC MEMBRANE AND SIMVASTATIN USING CBCT AFTER ENDODONTIC SURGERY : A RANDOMIZED CLINICAL TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/044782
Enrollment
36
Registered
2022-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis Health Condition 2: K046- Periapical abscess with sinus Health Condition 3: K047- Periapical abscess without sinus Health Condition 4: M275- Periradicular pathology associatedwith previous endodontic treatment Health Condition 5: K048- Radicular cyst

Interventions

Intervention1: Leucocyte -platelet rich Fibrin (L-PRF ): BONY CAVITY FORMED AFTER CURETTAGE OF PERI APICAL GRANULATION TISSUE/CYST WILL BE FILLED WITH Leucocyte -platelet rich Fibrin (L-PRF ) and sutu

Sponsors

Dr Niharika Singh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Age group 20-40 yrs. • Subjects having CBCT- periapical score 4 & 5. ( Diameter of periapical radiolucency >4-8 mm & >8mm respectively ) . This new PAI score was based on CBCT (CBCT-PAI) and introduced in 2008 by Estrela et al.[17] • Failed re-RCT with persistent sign and symptoms of infection eg. Swelling, sinus, pus discharge etc. • Subjects requiring periapical root end surgery involving anterior teeth. • Subjects with sufficient motivation and capable of reporting back to the clinic for follow up visits.

Exclusion criteria

Exclusion criteria: • Subjects diagnosed with diabetes mellitus or any systemic diseases which is likely to influence healing • Patients requiring re-apicoectomy. • Smokers and alcoholics. • Patients with bone disorders. • Patients with anomalies of blood and immune system. • Patients with malignant tumors and/ or on cancer therapy. • Pregnant females.

Design outcomes

Primary

MeasureTime frame
Percentage reduction in the size of periapical lesion which will be evaluated after 6 and 12 months postoperatively with CBCT Timepoint: 6 and 12 months after endodontic surgery with CBCT—

Secondary

MeasureTime frame
Reduction in oedema, post operative pain, signs of infection, sinus and tenderness on percussion which will be evaluated clinically after 1 week post operatively Timepoint: 1 week after endodontic surgery—

Countries

India

Contacts

Public ContactDr Rhythm Bains

King George Medical University

promilarajesh@yahoo.co.in9415542063

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026