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Effectiveness of probiotics in reducing oral malodor.

Effectiveness of Lactobacillus Salivarius-Wb21 Containing Tablets on Oral Malodor among Patients Attending Dental Institution in Mysuru city, India ââ?¬â?? A Double Blind Randomized Placebo-Controlled Crossover Trial.

Status
Recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/044776
Enrollment
48
Registered
2022-08-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R196- Halitosis

Interventions

Intervention1: Probiotic tablets: Dose: 1 tablet (Minna No Zendamakin WB21 Tablet
Wakamoto Pharmaceutical Co, Tokyo, Japan) containing 6.7 x 108 colony-forming units of L salivarius WB21 and 280 mg of xylitol per tablet. Route of administration: Oral Frequency: 3 times a day Durati

Sponsors

JSS Academy of Higher Education and Research
Lead Sponsor
Dr Nao Suzuki
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Willing to participate in the study More than 18 years of age Having oral malodor above a questionable level (OLT � 1.5) Not currently visiting a dentist for treatment Having one or more 3- to 6-mm periodontal pocket depth (PPD) that bleed on probing (BOP) Dentulous Having no daily smoking habit Having no adverse reactions to lactose or fermented milk products. Not using antibiotics within 3 months

Exclusion criteria

Exclusion criteria: Having acute symptoms requiring immediate oral cavity treatment Wearing prostheses Using probiotic supplements Having systemic illness

Design outcomes

Primary

MeasureTime frame
oral halitosis, tongue coating and plaque formation.Timepoint: Baseline and 14 days following intervention.

Secondary

MeasureTime frame
Probing pocket depth (PPD) Bleeding on probing Plaque score Tongue coatingTimepoint: Baseline and 14 days following intervention.

Countries

India

Contacts

Public ContactDr Chandrashekar BR

JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru.

drchandrubr@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026