Evaluating the effectiveness of locally applied melatonin gel in the treatment of advanced gum disease.

Melatonin, as a locally delivered drug in the treatment of periodontal infra bony defects - A randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/08/044750

Enrollment

Registered

2022-08-18

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K052- Aggressive periodontitis

Interventions

Intervention1: Phase I periodontal therapy.: Phase I periodontal therapy will be given as part of intervention along with injectable locally delivered melatonin gel. Dose:0.5% Frequncy:Once Duration

Eligibility

Inclusion criteria

Inclusion criteria: Aged above 18 years Willing to offer informed consent Having severe periodontitis

Exclusion criteria

Exclusion criteria: With known history of allergy or hypersensitivity to the drugs in trial Systemic diseases that compromise periodontal host defense mechanism History of use of antimicrobial drugs in the last three months

Design outcomes

Primary

Measure	Time frame
Clinical parameters like gingival index, probing pocket depth, clinical attachment loss, bleeding index and bone loss in test and control group will be assessed.Timepoint: Baseline, 6 weeks, 6 months	—

Secondary

Measure	Time frame
Radiological parameters using CBCT/IOPA will be evaluated at baseline and six months following intervention.Timepoint: Baseline and six months following intervention.	—

Countries

India

Contacts

Public ContactDr Chandrashekar BR

JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru.

drchandrubr@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026