Evaluation of the levels of immune response in teeth that have undergone cell death after placing simvastatin as an root canal medicine.

Quantitative Assessment of Interleukin-6(IL-6) in Teeth with Pulpal Necrosis and Symptomatic Apical Periodontitis Following Placement of Simvastatin as an Intracanal Medicament- A Prospective Triple-Blind Randomized Controlled Clinical Trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/08/044749

Enrollment

Registered

2022-08-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Simvastatin: 1.2 g/ 100ml Frequency/Duration for 7days. Control Intervention1: Calcium hydroxide: 1.2g/0.8ml Frequency/duration for 7 days

Eligibility

Inclusion criteria

Inclusion criteria: ASA score 1 Healthy patients aged 16-60 years patients diagnosed with pulpal necrosis and symptomatic apical periodontitis (PAI =2) Single rooted teeth with single canal and closed apex

Exclusion criteria

Exclusion criteria: Patients under ASA 2-5 category. Patients under any medication for a week. Patients with periapical pathology (PAI score >2) Teeth with cracks, vertical root fracture, internal & external resorption. Multirooted teeth, Single rooted teeth with multiple canals. Teeth with immature apex.

Design outcomes

Primary

Measure	Time frame
Quantification and comparison of Interleukin-6 before and after placement of simvastatin will show decrease in its concentrationTimepoint: Samples will be taken before and after biomechanics preparation and after 7 days of intracanal medication placement.	—

Secondary

Measure	Time frame
Quantification and comparison of Interleukin-6 before and after placement of Calcium hydroxide will show decrease in its concentration.Timepoint: Samples will be taken before and after biomechanics preparation and after 7 days of intracanal medication placement.	—

Countries

India

Contacts

Public ContactDr Ravikumar N

SRM Dental College

kavithasanjeev02@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026