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A study of immune imbalance in migraine patients

A perspective case-controlled study 0f FOXP3 gene mutation in migraine patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/08/044663
Enrollment
50
Registered
2022-08-05
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G439- Migraine, unspecified

Interventions

Control Intervention1: NIL: Nil

Sponsors

Sri Ramachandra Institute of Higher Education and Research DU
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Migraine with aura (MWA) and Migraine without aura (MWOA) patients 2.Patients above 18 years old 3.Patients affected by COVID-19 4.Patients who have all been vaccinated against COVID-19, either with both doses or a single dose

Exclusion criteria

Exclusion criteria: 1.Patients with additional comorbidity conditions were not allowed to participate. 2.Patients who have recently taken any immunosuppressants 3.Pregnant women were excluded 4.Patients with previous head injury

Design outcomes

Primary

MeasureTime frame
This study will identify the 1. Autoantibody levels in migraine patients using various antibody tests and will confirm the immune dysfunction during migraine attacks in patients. 2. The specific mutation of FOXP3 gene in migraine patients using RT-PCR assay which will be helpful to us to understand on the pathophysiology of migraine.Timepoint: Investigation of 6 months

Secondary

MeasureTime frame
Secondary outcome include the detection of autoantibody level and FOXP3 gene specific mutation which will give better understanding of migraine as an autoimmune disorderTimepoint: Investigation of 1 year

Countries

India

Contacts

Public ContactSubalakshmi S

Sri Ramachandra Institute of Higher Education and Research

murugesan.a@sriramachandra.edu.in8870151588

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026