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To compare different effects and fall in blood pressure of spinal anesthesia while using the following drugs 1. fentanyl and bupivacaine together 2. fentanyl after bupivacaine 3. bupivacaine after fentanyl in orthopedic surgeries of lower limb.

Comparison of Efficacy of premixed versus succedent administration of fentanyl and bupivacaine in subarachnoid block in lower limb surgeries: A prospective double blinded randomized interventional study at S.M.S. Medical College, Jaipur during 2021-2023.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/044656
Enrollment
90
Registered
2022-08-04
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection bupivacaine 0.5% 2.5ml and injection fentanyl 0.5ml in different syringes: Injection fentanyl 0.5 ml followed by injection bupivacaine 0.5% 2.5ml intrathecally in subarachnoi

Sponsors

Department of Anaesthesiology Sawai Man Singh Medical College And Attached Hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients in the age group between 18 to 70 years 2 ASA Grade 1 and 2 3. Body weight 45 to 70 kg 4. Undergoing lower limb surgeries like orthopedic procedures

Exclusion criteria

Exclusion criteria: 1. Patients not willing to participate in the study. 2. Cases with sepsis, bacteremia or skin infection of local site. 3. Hitory of hypovolemia, anemia and compromised renal, cardiac or respiratory status. 4. Cases with increased intracranial tension. 5. History of blood coagulopathy. 6. Patients allergic to drugs used for study. 7. Failure of spinal anaesthesia.

Design outcomes

Primary

MeasureTime frame
To determine the difference in mean time of onset of sensory and motor block in three different groups.Timepoint: 24 hours—

Secondary

MeasureTime frame
1. To determine the difference in mean time of two segment regression of sensory levels. 2. To determine the difference in change in hemodynamic changes from baseline to different time interval in three groups.Timepoint: 24 hours—

Countries

India

Contacts

Public ContactDr Ruchi

Sawai Man Singh Medical College And Attached Hospitals

drsavita020@gmail.com8290969216

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026