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CLINICAL, MICROBIOLOGICAL AND IMMUNOLOGICAL EVALUATION OF THE EFFICACY OF ORALY ADMINISTERED PROBIOTIC BACILLUS COAGULANS AND STREPTOCOCCUS SALIVARIUS AS AN ADJUVANT TO SCALING AND ROOT PLANING IN PERIODONTITIS PATIENTS: A RANDOMIZED CLINICAL STUDY

EVALUATION OF THE EFFICACY OF ORALY ADMINISTERED PROBIOTIC BACILLUS COAGULANS AND STREPTOCOCCUS SALIVARIUS AS AN ADJUVANT TO SCALING AND ROOT PLANING IN PERIODONTITIS PATIENTS: A RANDOMIZED CLINICAL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/08/044650
Enrollment
60
Registered
2022-08-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Test Group 2 Patients receiving Scaling and Root Planing plus Streptococcus salivarius UBSS-01 -2 billion cfu per sachet : DOSAGE-one sachet daily after 1 hour of dinner for 30 days,

Sponsors

Unique Biotech Ltd
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a. Age between 30-65years. b. Patients with stage II and stage III periodontitis according to AAP 2017 classification will be included.10 c)30% or more of sites with probing pocket depth (PPD>= 4mm and CAL>=4mm d)A minimum of five teeth with at least one site with CAL and PPD>=4mm.

Exclusion criteria

Exclusion criteria: a. Antimicrobial therapy in the previous three months b. Presence of systemic conditions c. History of smoking d. Need of prophylactic antibiotic therapy for routine dental procedures. e. long term administration of anti-inflammatory medications. f. Usage of probiotics in the past six months before the study.

Design outcomes

Primary

MeasureTime frame
Probing pocket depth assessed at six sites per tooth. Microbiological counts of Porphyromonas gingivalis Microbiological counts of Bacillus coagulans and Streptococcus salivarius Levels of IL6.Timepoint: BASELINE, 1 MONTH AND 3 MONTHS FOLLOWING PROBIOTIC AND PLACEBO INTERVENTION—

Secondary

MeasureTime frame
Clinical Attachment Level CAL assessed at six sites per tooth. Plaque Index Silness and Loe 1964 Gingival Index Loe and Silness 1963 Timepoint: BASELINE, 1 MONTH AND 3 MONTHS FOLLOWING PROBIOTIC AND PLACEBO INTERVENTION—

Countries

India

Contacts

Public ContactDR AYSHA JEBIN A

KRISHNADEVARAYA COLLEGE OF DENTAL SCIENCES

ayshpathu3@gmail.com9895205190

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026