Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Procalcitonin: procalcitonin levels will be tested and antibiotics wil be started or stopped based on procalcitonin value
Control Intervention1: No special investigation: No special inv
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients over the age of 18 years of age 2. A diagnosis of acute pancreatitis requiring two of the following three features [7]: I. abdominal pain consistent with acute pancreatitis (acute onset of a persistent, severe, epigastric pain often radiating to the back) II. serum lipase activity (or amylase activity) at least three times greater than the upper limit of normal III. Characteristic findings of acute pancreatitis on contrast-enhanced computed tomography (CECT), magnetic resonance imaging (MR) or transabdominal ultrasonography
Exclusion criteria
Exclusion criteria: 1. Comorbidities requiring prolonged antibiotic therapyââ?¬â?such as infective endocarditis 2. Severely immunocompromised patientsââ?¬â?such as those with human immunodeficiency virus and with a CD4 count of less than 200 cells/mm3 ; neutropenic patients ( 3. Patients on immunosuppressive therapy 4. Previous thyroid surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare antibiotic usage in terms of Daily Defined Dose (DDD) between patients treated conventionally and those in which treatment is guided by procalcitonin levels.Timepoint: 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Mortality of the patient, 2)Length of hospital stay, 3)Clinical infections such as pneumonia, enteritis or intra-abdominal infection 4)Isolates of multi-resistant bacteria from the intra-abdominal collection aspirates, 5)Incidence of multi-resistant organism bacteraemia, 6)Incidence of infected pancreatic necrosis (IPN)ââ?¬â?defined either as a result of fine needle aspiration (FNA), radiological evidence of gas in a peri-pancreatic collection or positive microbiological cultures from surgical or post-mortem specimens, 7)Need for radiological, endoscopic or surgical intervention, 8)Survival at 90 days (through telephonic follow up), 9)Re-admission to hospital within 4 weeks of onset of index episode (through telephonic follow up). Timepoint: All the secondary outcomes are taken into consideration within 90 days of hospital admission | — |
Countries
India
Contacts
Public Contactchakravarthy
JIPMER
Outcome results
None listed