Health Condition 1: C710- Malignant neoplasm of cerebrum, except lobes and ventricles
Conditions
Interventions
Intervention1: DEXMEDETOMIDNE: Dexmedetomidine (infusion) 0.2 to 0.7 mcg/kg/hr will be used with scalp block for multimodal opioid free anaesthetic technique in elective supratentorial craniotomies. D
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent 2. Undergoing craniotomy for elective supratentorial tumour excisions, size 3. American Society of Anesthesiologists class I&II
Exclusion criteria
Exclusion criteria: 1. Patient’s refusal 2. Anticipated difficult airway/ intubation including those with cervical spine disease. 3. Pregnancy 4. Body mass index of > 35 kg/m2 5. Patients who had sensitivity to opioids, dexmedetomidine, ropivacaine (study drugs) 6. Patients with cardiovascular diseases or respiratory diseases 7. Previous history of craniotomy or any intracranial procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary: To compare opioid free anesthetic technique with conventional opioid based anesthetic technique in terms of emergence from anaesthesia in patients undergoing elective supratentorial craniotomy. 1.Emergence time (in minutes) 2.Extubation time (in minutes) Timepoint: At emergence and extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intraoperative Hemodynamic response, such as heart rate and mean art. Pressure. 2. Rate of Post operative nausea vomiting [PONV] 3. Postoperative pain assessed post extubation in OT and subsequently at 4,6,12 and 24 hours in ICU using the 11- point Numeric Rating Scale. 4. Emergence quality assessed using Richmond Agitation Sedation Scale. 5. Duration of ICU stay (days) 6. Duration of hospital stay (days) 7. Complications if any. Timepoint: Baseline, intraoperative period, and till 24hrs in ICU | — |
Countries
India
Contacts
Public ContactDAVINDER JIT SINGH
AIIMS, NEW DELHI
Outcome results
None listed