Health Condition 1: G610- Guillain-Barre syndrome
Conditions
Interventions
Sponsors
National Institute of Mental Health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: � Patients aged 18 to 70 years, fulfilling the National Institute of Neurological Disorders and Stroke (NINDS) criteria for GBS and Brighton level of certainty of diagnosis of one or two. � Patients requiring ICU admission
Exclusion criteria
Exclusion criteria: � Refusal of consent � Patients with cardiac failure, renal or liver failure � Preexisting uni- or bilateral diaphragmatic paralysis � Severe sepsis with inotropic support
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ââ?¬Â¢ To estimate the diaphragm thickness, DTF, excursion, and velocity of contraction measured by ultrasound at ICU admission in patients with GBS requiring tracheal intubation and MVTimepoint: At the admission to ICU or initiation of mechanical ventilation (baseline), thereafter weekly once for a maximum of 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the effect of baseline diaphragm parameters by ultrasound on the duration of MV and ICU stay.Timepoint: Baseline values;To determine the effect of changes in diaphragm measurements by ultrasound on the weaning success.Timepoint: At the time of first weaning trial (5 min after disconnection from ventilator and then 30 min after disconnection) | — |
Countries
India
Contacts
Public ContactRajeeb Kumar Mishra
National Institute of Mental Health and Neurosciences
Outcome results
None listed