Health Condition 1: C169- Malignant neoplasm of stomach, unspecified
Conditions
Interventions
Intervention1: Probiotics: Participants will receive two probiotic sachets (0.5gm each) with early enteral feeds twice a day until day 10 after surgery. Each sachet consists of Streptococcus faecalis
Sponsors
IMRF Intramural research fund JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: All patients who are more than 18 years of age, undergoing subtotal gastrectomy for carcinoma stomach
Exclusion criteria
Exclusion criteria: 1. All patients who have received probiotics for a duration of 6 months before surgery. 2. Patients undergoing laparoscopic gastrectomy. 3. Recurrent carcinoma of stomach. 4. Presence of other malignancy. 5. Received neoadjuvant therapy. 6. Patients diagnosed with IBD. 7. Patients with coexistence of severe concomitant illness like organ failures 8. Immunocompromised patients. 9. Pregnancy or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine if the administration of probiotic will reduce the length of hospital stay and inflammatory markers (TNF-alpha,TLC, IL-6, IL-8 ) in patients undergoing surgical resection for gastric cancer. Timepoint: pre operative, post operative day 10 | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the role of probiotics in patients undergoing surgery for gastric cancer on the following: 1. Postoperative clinical outcomes((time to return of bowel movement as measured by passage of flatus, time to first passage of stools, time to start of oral diet, duration of drains kept, duration of antibiotic therapy, length of hospital stay, mortality, post operative complications such as fever, surgical site infection, anastomotic leak, stump blow out, vomiting, diarrhea, pulmonary infection, intolerance to early enteral feed and Clavien-Dindo grading of post-operative complications) 2. Nutritional status (hemoglobin, albumin, BMI and transferrin) 3. Immune function (levels of IgG, IgA and IgM) 4. Risk Factors for the postoperative complication Timepoint: pre operative, post operative day 10 | — |
Countries
India
Contacts
Public ContactDr Debolina Pal
JIPMER
Outcome results
None listed