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To compare the effects of two drug groups, levobupivacaine and dexmedetomidine with ropivacaine and dexmedetomidine for intraperitoneal injection after laparoscopic gall bladder removal.

Evaluation of postoperative analgesic effect of intraperitoneal instillation of 0.125% levobupivacaine + 1 μg/kg dexmedetomidine or 0.2% ropivacaine +1 μg/kg dexmedetomidine after laparoscopic cholecystectomy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/044455
Enrollment
60
Registered
2022-07-28
Start date
Unknown
Completion date
Unknown
Last updated
2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: INTRAPERITONEAL INSTILLATION of 0.125% LEVOBUPIVACAINE PLUS 1microgram/kg DEXMEDETOMIDINE: intraperitoneal instillation of 0.125% levobupivacaine 40ml + dexmedetomidine 1microgram/kg m

Sponsors

JLN medical college Ajmer
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient belonging to ASA I and II 2.Gall bladder calculi.

Exclusion criteria

Exclusion criteria: 1. ASA grade III and above. 2. age 60 years. 3. patients with severe systemic disease like IDDM, uncontrolled hypertension, kidney and liver disease, severe respiratory disease. 4. seizure disorder. 5. CAD or recent history of MI. 6. Anticipated difficult intubation. 7. body weight >100kg or obese. 8. pregnant and lactating women. 9. patient of psychiatric disorder and sleep disorders. 10.hypersensitivity to study drugs. 11.conversion of laparoscopic cholecystectomy to open cholecystectomy.

Design outcomes

Primary

MeasureTime frame
1. Duration of post operative analgesia.Timepoint: 1. Duration of post operative analgesia at 0,1,2,4,6,8,10,12,24 hours.—

Secondary

MeasureTime frame
1.total rescue analgesic required in 24 hours. 2. hemodyanamic changes. 3. side effects like hypotension,bradycardia,postoperative nausea and vomiting,sedation,respiratory depression,pruritus and any other.Timepoint: 1. Duration of post operative analgesia at 0,1,2,4,6,8,10,12,24 hours.—

Countries

India

Contacts

Public ContactDr Neena Jain

JLN Medical collage Ajmer

drneenaj@gmail.com9414008666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026