FindTrial
Sign In

To compare between opioid free and opioid based drugs in general anesthesia

Comparison of opioid free anaesthesia versus opioid based anaesthesia under general anaesthesia-A double blinded randomized control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/044316
Enrollment
108
Registered
2022-07-25
Start date
Unknown
Completion date
Unknown
Last updated
2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Opioid based drugs: patient will receive opioid based anesthesia induced with fentanyl 2mcg/kg infusion dilated in a 20ml syringe given IV over 10 mins and propofol 2.5mg/kg IV and par

Sponsors

Pondicherry Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2, patients posted for elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: Known Allergy to study drugs Opioid used 1 month prior to surgery Chronic opioid addiction Pregnant and lactating mothers Patients with cardiac insufficiency Mental incapacity of patient to comprehend pain assessment/psychiatric disease

Design outcomes

Primary

MeasureTime frame
To compare analgesic requirement at 1st post operative hour based on VAS score in patients undergoing general surgery between opioid free anaesthesia and opioid based anaesthesia groupsTimepoint: 120 minutes—

Secondary

MeasureTime frame
1) assess Extubation time. 2) To determine VAS score at 15 mins, 30 mins, 45 mins, 60 mins,90 mins, 2hrs, 4hrs, 8hrs, 12hrs, 16 hrs, 24hrs 3) To determine hemodynamic response â?? Intraoperative /postoperative period 4) Total analgesic requirement for 24 hrs 5) To assess complications if any ( PONV /shivering /bradycardia,hypotension, respiratory depression Timepoint: 24 hours—

Countries

India

Contacts

Public ContactNarendran A

Pondicherry Institute of Medical Sciences

vedha83@gmail.com9894510137

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026