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Investigator initiated study for comparison of ART outcome in 0.2 mg GnRH agonist trigger

Comparison of ART outcome in 0.2 mg GnRH agonist trigger vs Dual trigger trigger in Poor ovarian reserve females, a randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/044258
Enrollment
654
Registered
2022-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O090- Supervision of pregnancy with history of infertility

Interventions

Intervention1: Agonist trigger: Agonist trigger final oocyte maturation trigger using 0.2mg triptorelin acetate (GnRH agonist) SC Control Intervention1: Dual trigger: Dual trigger final oocyte maturat

Sponsors

Indira IVF Hospital Udaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age 25- 40 years 2. Antral follicle count on day 2 of menses less than 5 3.AMH less than 1.2 ng per dl

Exclusion criteria

Exclusion criteria: 1. BMI; >= 30 kg/m2 2. Presence of endocrine disorders; (uncontrolled diabetes mellitus, / hyperprolactinemia, thyroid dysfunction, 3. Congenital adrenal hyperplasia, Cushing syndrome, or polycystic ovary syndrome 4. Previous major uterine surgery 5. Donor oocyte cycle. 6. Gestational carrier 7. Fertility preservation. 8. Adenomyosis 9. Endometriosis 10. Premature ovarian failure. 11. Thin endometrium

Design outcomes

Primary

MeasureTime frame
Percentage of mature oocytes retrieval Timepoint: On the day of ovum pick-up 10- 15 days of start of simulation

Secondary

MeasureTime frame
Follicle oocyte index Timepoint: On the day of ovum pick-up 10- 15 days of start of simulation;Clinical pregnancy rateTimepoint: 4-6 weeks after embryo transfer;Implantation rateTimepoint: 4- 6 weeks after embryo transfer;OHSS occurrence rateTimepoint: 4 weeks from ovum pick up;Ongoing pregnancy rateTimepoint: 12th week of gestation;Oocyte retrieval rateTimepoint: On the day of ovum pick-up 10- 15 days of start of simulation

Countries

India

Contacts

Public ContactDr Vipin Chandra

Indira IVF Hospital Pvt Ltd

drvipinchandra@indiraivf.in9567971239

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026