Health Condition 1: N186- End stage renal disease
Conditions
Interventions
Intervention1: IVC Distensibility guided fluid therapy: Basal intravenous fluid (balanced salt solution) will be given at rate of 2ml/kg/hr. Inferior Vena Cava Diameter can be measured by ultrasound.D
Sponsors
Tapas Kumar SIngh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age : 18 -60 years, 2.Living donor 3.ASA III 4. Undergoing renal transplant under general anaesthesia 5.Informed written consent 6.Easy sonoanatomy for IVC visualisation. 7.No or Less than 500 ml urine output per day
Exclusion criteria
Exclusion criteria: 1.Impaired RV/LV function and ejection fraction or any ischaemic or other structural heart diseases 2.Morbid obesity, 3.Any lesion obscuring sonoanatomy 4.ABO incompatible 5.Central monitoring site other than Superior vena cava
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total fluid given in intraoperative period before kidney reperfusionTimepoint: at time just before clamp opening in both groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline and after surgery P/F ratiosTimepoint: end of surgery;Correlation between IVC distensibility and CVP valuesTimepoint: after intubation & CVP insertion after kidney bed is ready after skin closure;Day 1 and 2 Urine outputTimepoint: end of POD1 and POD 2;Difference in preoperative and post-operative lactate levels and Standard Base Excess in arterial blood gasTimepoint: end of surgery;Fall in creatinine levels till day 5Timepoint: end of POD5;Incidence of acute rejection in 3 months follow upTimepoint: end of three months;Incidence of breathlessness in postoperative periodTimepoint: end of POD1;Max fall in Mean Arterial pressures in one minute post clamp openingTimepoint: at the time of clamp opening;Total Noradrenaline used in intra operative periodTimepoint: at the end of surgery;Use of other vasopressors or inotropes other noradrenalineTimepoint: end of surgery | — |
Countries
India
Contacts
Public ContactTapas kumar singh
SGPGI
Outcome results
None listed