Effectiveness of infiltration with buffered 4% articaine hydrochloride with 1:200,000 epinephrine for pulp therapy in primary second mandibular molar and permanent first mandibular molar

Anesthetic efficacy of supraperiosteal buffered articaine injection for pulp therapy in primary second mandibular molar and first permanent mandibular molar. A Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/07/044085

Enrollment

Registered

2022-07-18

Start date

Unknown

Completion date

Unknown

Last updated

2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Buffered 4% articaine with 1:200000 epinephrine: 8.4% sodium bicarbonate is used for buffering. From 1.8 ml articaine cartridge 0.18 ml of solution will be discarded to create space for

Eligibility

Inclusion criteria

Inclusion criteria: 1. American society of Anaesthesiologists (ASA) 1 children. 2. Children reporting to the department with vital teeth requiring access opening as a part of pulp treatment in primary mandibular second molar or permanent mandibular first molar under local anaesthesia

Exclusion criteria

Exclusion criteria: 1. Frankl definitely negative children. 2. Children with history of allergy to local anesthesia

Design outcomes

Primary

Measure	Time frame
To compare and evaluate the effectiveness of supraperiosteal injection of buffered 4% articaine hydrochloride and 4% articaine hydrochloride with 1:200,000 epinephrine for pulpal procedures in primary mandibular second molars and permanent mandibular first molars using Face, Legs, Activity, Cry, Consolability Scale . Timepoint: 1 year	—

Secondary

Measure	Time frame
To evaluate for any side effects of 4% buffered articaine solution on administration of supraperiosteal injection.Timepoint: 1 year	—

Countries

India

Contacts

Public ContactDr Sushmitha P

Manipal College of Dental Sciences

ashwin.rao@manipal.edu9342466688

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026