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comparison of ropivacaine (a local anesthetic) and dexmedetomidine when given through nebulisation (steam vapours) on the heart rate and blood pressure during start of surgery under general anesthesia

Comparison of nebulised ropivacaine 0.75%, nebulised dexmedetomidine on hemodynamic response on intubation in patients undergoing surgery under general anaesthesia : A comparative double blind placebo controlled study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/044029
Enrollment
180
Registered
2022-07-14
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Ropivacaine: Patients will receive ultrasonic nebulisation with 0.75% ropivacaine (5 ml) for 10 minutes Control Intervention1: Dexmedetomidine: Patients will receive ultrasonic nebulisa

Sponsors

Dr B R Ambedkar State Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.American Society of Anesthesiologists (ASA) physical status I - II 2.Age â?? 18-60 years 3. Scheduled to undergo elective surgery of duration < 2 hours under general anaesthesiaÂ

Exclusion criteria

Exclusion criteria: 1.Patient with pre operative sore throat or upper respiratory tract infection 2.Patients with history of allergy to local anesthestics 3.Patents with history of allergy to Dexmedetomidine 4.Patients with history of cardiac, liver or renal disorders. 5. Patient with anticipated difficult airway with anticipated duration of laryngoscopy > 15 seconds 6. patients who refuse to participate

Design outcomes

Primary

MeasureTime frame
To compare the hemodynamic response of nebulised ropivacaine 0.75% with nebulised dexmedetomidine and with saline during intubation in patients undergoing surgery under general anesthesia. Timepoint: before and after nebulisation, before intubation, at the time of intubation and 5 minutes after intubation—

Secondary

MeasureTime frame
to assess for post operative sore throatTimepoint: 0,2,4,6,12,24 hours;To compare cough response after extubationTimepoint: 0 ,5 and 30 minutes;To compare the hemodynamic parameters at extubation. Timepoint: at time of extubation, 5 minutes after extubation—

Countries

India

Contacts

Public ContactDr Ravneet Kaur Gill

Dr B R Ambedkar State Institute of Medical Sciences

drravneetkgill@gmail.com9501988361

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026