Evaluation of pain before and after root canal treatment following various irrigation protocols

Comparative evaluation of post endodontic pain following various irrigation protocols using Sodium Hypochlorite, Ethylenediamine tetraacetic acid with/without Nisin and Etidronic acid â?? An Observational study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/07/044014

Enrollment

126

Registered

2022-07-14

Start date

Unknown

Completion date

Unknown

Last updated

2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Naocl and Nisin incorporated EDTA: 2.5%, 10 ml for 10 minutes Intervention2: Naocl and Etidronic acid: 2.5% Naocl and 9% Etidronic acid, 10ml for 10 minutes Control Intervention1: NaOcl

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients under ASA I & II category. 2. Mandibular or maxillary teeth with closed apex. 3. Patients diagnosed with symptomatic irreversible pulpitis with apical periodontitis and/or pulpal necrosis

Exclusion criteria

Exclusion criteria: 1. Patients under ASA III-V category. 2. Patients with other systemic diseases 3. Patients under any antibiotic medication for a week. 4. Teeth with cracks, vertical root fracture, internal & external resorption. 5. Teeth with immature apex

Design outcomes

Primary

Measure	Time frame
N-EDTA can effectively disinfect the root canal alleviating symptomatic irreversible pulpitis with/without apical periodontitis.Timepoint: 3hrs, 24hrs, 48hrs and 7 days	—

Secondary

Measure	Time frame
Continuous chelation, if proven to be effective, can be substituted with sequential irrigation, eliminating the two step irrigation protocol.Timepoint: 3hrs, 24hrs, 48hrs and 7 days.	—

Countries

India

Contacts

Public ContactDr M Madhana Madhubala

SRM Institute of Science and Technology

reasearchmaha@gmail.com9381018598

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026